Cortical brain changes from early to mid-adolescence in offspring at familial high risk for schizophrenia or bipolar disorder

Objective: Schizophrenia (SZ) and bipolar disorder (BP) emerge in late adolescence or adulthood. Offspring at familial high risk for SZ (FHR-SZ) or BP (FHR-BP) are more likely to develop psychiatric disorders. Prior work from the Danish High Risk and Resilience (VIA) Study found sex-specific volumetric brain differences in offspring at FHR-SZ and FHR-BP aged 11-12 years. This study builds upon these findings by testing whether they reflect group differences in rate of change or stable group differences from early to mid-adolescence. Methods: This study investigated MRI data from offspring at F

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