CCL17-CCR4 Signalling Attenuates Pressure Overload-Induced Cardiac Remodelling Through IGFBP6 Suppression in Cardiac Fibroblasts

Background and Aims Chemokines regulate immune-cell trafficking, inflammation, and tissue repair in cardiovascular disease. C-C motif chemokine ligand 17 (CCL17) has been linked to adverse remodelling after myocardial infarction and neurohumoral stress, but its role during sustained mechanical pressure overload remains unclear. We investigated whether CCL17 regulates ventricular remodelling through signalling in cardiac fibroblasts. Methods We performed serum proteomic screening and assessed CCL17 in human serum and myocardial samples. We evaluated CCL17 function in mice subjected to transvers

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