medRxiv PreprintsInternational12 November 2026
Beat-to-beat blood pressure variability and Alzheimers disease pathophysiology
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Introduction: Elevated blood pressure variability (BPV) is predictive of Alzheimers disease neuropathologic change observed with AD biomarkers. However, prior studies have largely focused on visit-to-visit BPV, which may be influenced by antihypertensive medication adherence and other external factors. Few studies have investigated beat-to-beat BPV, a reliable and direct measure of cardiovascular and autonomic function relevant to AD. Methods: Independently living older adults (N=132) were recruited from the community. Participants underwent continuous blood pressure monitoring and venipunctur
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