medRxiv PreprintsInternational9 November 2026
Automated MRI-Based Segmentation of the Cranio-Cervical Venous System Using a Dedicated Deep Learning Pipeline
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PURPOSE To develop an automated magnetic resonance imaging based segmentation pipeline for the cranio-cervical venous system (CCVS), a complex anatomical network for which no dedicated segmentation tool is currently available. MATERIALS AND METHODS A retrospective single-center cohort of 194 contrast-enhanced cranio-cervical MRI examinations acquired between 2019 and 2024 was used. Manual reference segmentations were performed on 50 examinations using 3D Slicer. A nnU-Net v2-based segmentation model was trained through an iterative process combining automatic segmentation, manual correction, a
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