Atrophy-related inflammation CSF markers predict clinical progression in genetic frontotemporal dementia

Neuroinflammation is increasingly recognised as a key contributor to frontotemporal dementia (FTD) pathophysiology, yet how inflammatory processes relate to neurodegeneration and clinical progression remains poorly defined. This study aimed to identify a multivariate cerebrospinal fluid (CSF) inflammatory signature covarying with brain atrophy, and to determine its relevance to clinical and cognitive outcomes in genetic FTD. We recruited 234 participants (non-carrier controls n=78, presymptomatic carriers n=115, symptomatic carriers n=41) with CSF, MRI, and clinical (CDR (r) + NACC FTLD sum of

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