medRxiv PreprintsInternational8 November 2026
An early activated CD38highCD209highCD36low monocyte phenotype is associated with progression to severe dengue
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Background: Although monocytes are among the principal target cells of dengue virus (DENV) infection we sought to investigate monocyte phenotypic markers associated with disease severity and evaluate their potential as prognostic biomarkers and therapeutic targets. Methods: Differences in monocyte subpopulations and phenotypic markers were assessed by flow cytometry in patients with dengue fever (DF=33) and dengue haemorrhagic fever (DHF=21) and compared to health controls (HCs=20). Further in vitro experiments were done by co-culturing peripheral blood mononucleocytes (PBMCs) of healthy indiv
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