medRxiv PreprintsInternational12 November 2026
An agent-based model of Epstein-Barr virus transmission and vaccination
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Epstein- Barr virus (EBV) infects over 90% of adults worldwide, causing infectious mononucleosis (IM) in adolescents and young adults and contributing to multiple malignancies. Despite its global burden, population- level transmission modeling of EBV remains limited. We present the first population- level agent-based model (ABM) of EBV transmission. The model is implemented with 10,000 agents and calibrated to age-specific seroprevalence data from the US National Health and Nutrition Examination Survey. Two complementary calibration methods are evaluated, each with its own distinct advantages:
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