Altered herpesvirus-specific immune response is associated with long COVID

Long COVID is associated with persistent immune dysregulation, but whether immunity to latent viruses is also altered remains unclear. We profiled herpesvirus-specific antibodies and T-cell responses in people with long COVID and recovered convalescent controls at 4, 8, and 24 months after SAR-CoV-2 infection. Overall antibody reactivity and abundance against cytomegalovirus (CMV) and Epstein-Barr virus (EBV) responder frequencies and circulating B-cell subsets were broadly preserved, but early antibody avidity and virus-specific CD4 T cell response magnitude were reduced. Neither virus nuclei

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