medRxiv PreprintsInternational8 November 2026
Accounting for Insulin-on-board in Large Language Model Advice about Pediatric Hyperglycemia
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Large language models (LLMs) can be used by patients and caregivers to answer medical questions and the characterization of safety concerns in LLM outputs for patient-facing applications is an active area of research. In this work, we study LLM responses to caregiver questions about hyperglycemia in pediatric type 1 diabetes. We measure the frequency of a potential safety failure: advice to dose insulin in the absence of a clear warning to account for insulin-on-board. We found occurrences of the potential safety failure across four LLMs tested through programmatic endpoints and two LLMs teste
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