Waist-to-Height Ratio Identifies Cardiometabolic Risk Not Captured by Body Mass Index: The All of Us Research Program

Background: Body mass index (BMI) does not characterize central adiposity and may obscure cardiometabolic risk among adults classified as normal weight. We evaluated associations between waist-to-height ratio (WHtR) and incident disease across the BMI spectrum and among adults with normal BMI. Methods: We studied 308,600 adults in the All of Us Research Program. Participants with the corresponding prevalent disease were excluded separately for eight cardiometabolic outcomes. Cause-specific Cox models adjusted for demographic, socioeconomic, smoking, and BMI-related factors. We evaluated contin

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