Ultra-rare coding variants in schizophrenia risk genes are associated with longitudinal phenotypic differences across psychotic disorders

Background: The Schizophrenia Exome Meta-Analysis (SCHEMA) Consortium has recently identified 40 genes at a false discovery rate <0.05 in which ultra-rare damaging variants substantially increase schizophrenia (SZ) risk. However, the impact of these variants on clinical trajectories across the psychosis spectrum is not yet known. Methods: We screened 9,821 sequenced participants with psychotic disorders who passed genomic quality control from the SUPER-Finland psychosis study for ultra-rare variants predicted to be damaging in these 40 SZ-associated genes, identifying 163 variant carriers. To

This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program: especially if you are pregnant, nursing, taking medication, or managing a health condition.