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medRxiv PreprintsInternational28 October 2026

Ultra-high-resolution Photon-Counting CT for Leaflet-Specific Evaluation of Fibrosis and Calcification in Aortic Stenosis

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Objectives: Ultra-high-resolution photon-counting detector (PCD)-CT may enable leaflet-specific analysis of aortic valve fibrosis and calcification, providing insights into early aortic stenosis (AS) disease progression. This study aimed to investigate how PCD-CT leaflet-specific calcific and fibrotic volumes influence cardiovascular magnetic resonance (CMR) leaflet mobility. Materials and methods: Participants with moderate aortic AS prospectively underwent both PCD-CT (n=80) and CMR (n=58). Using PCD-CT, calcific and fibrotic volumes were segmented for right (RCC), left (LCC), and non-corona
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