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medRxiv PreprintsInternational6 November 2026

Trends in gout management before and after publication of NICE guidance in England: a population-based study in OpenSAFELY

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Objectives: To evaluate gout management in England before and after publication of a national clinical guideline by the National Institute for Health and Care Excellence (NICE) and assess the feasibility of using routinely collected health data to monitor guideline implementation at scale. Design: Observational cohort study with interrupted time-series analysis. Setting: Primary care and hospital admission data, with the approval of NHS England. Participants: 22,618,945 individuals aged 18 to 110 years registered with general practices in England contributing data to the NHS OpenSAFELY Data An
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