Transdiagnostic Functional Brain Alterations Across Familial and Phenotypic Risk Samples: A Meta-Analysis

Importance: Psychiatric risk factors are often associated with multiple clinical outcomes. However, it remains unclear whether functional brain activation changes are shared across risk for mood, anxiety, and psychotic disorders. Objective: To determine which patterns of functional brain activation are shared across risk for different psychiatric disorders, defined using phenotypic (e.g., clinical) and familial risk paradigms, relative to control samples. Data Sources: PubMed and Web of Science were searched for task-based functional magnetic resonance imaging (fMRI) studies involving samples

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