Trajectories of Estimated Glucose Disposal Rate and Risk of Cardiovascular Disease: Evidence from Two Prospective Cohorts

Background Estimated glucose disposal rate (eGDR) is an accessible surrogate of insulin sensitivity and has been associated with cardiovascular disease (CVD) risk. However, whether longitudinal eGDR trajectory patterns convey prognostic information beyond cumulative eGDR exposure remains unclear. We aimed to characterize distinct eGDR trajectories and evaluate their associations with incident CVD in two prospective cohorts. Methods We included 4,823 CVD-free adults aged 45 years or older from the Health and Retirement Study (HRS, n=3,258) and the English Longitudinal Study of Ageing (ELSA, n=1

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