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medRxiv PreprintsInternational28 October 2026

Toxoplasma gondii genotyping in 2,467 human toxoplasmosis cases from France and other geographical origins: genetic diversity and clinical associations

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Background Toxoplasma gondii exhibits marked variation in genetic diversity, yet the relationships between parasite genotype and clinical presentation in humans remain poorly understood. We investigated the diversity of T. gondii strains infecting humans and their associations with different forms of toxoplasmosis. Methodology/Principal Findings We retrospectively analyzed 2,467 T. gondii-positive human clinical cases collected in France through a nationwide network of hospital parasitology diagnostic units over more than four decades. Cases included patients receiving care in mainland France,
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