Time of Day Dependent Effectiveness of Anti-IgE Therapy in Asthma: Clinical and Experimental Evidence

Background: Asthma is a time-sensitive inflammatory disease whose activity exhibits daily (circadian) rhythms. An outstanding question is whether such temporal variations extend to advanced asthma treatments like biologics that are used for moderate-to-severe disease. Objective: To examine how time-of-administration relates to the effectiveness of the anti-IgE biologic, omalizumab. Methods: We performed a retrospective cohort study of omalizumab effectiveness in 153 patients with asthma with timestamped administration records. Time of day was modeled as a continuous variable and dichotomized i

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