Therapeutic acute intermittent hypoxia alters supraspinal neural control of lower limb movement in multiple sclerosis

Acute intermittent hypoxia (AIH) therapy is a promising neurorehabilitative intervention with well-documented enhancements in motor function in people with spinal cord injury. Its enhancements in lower-limb motor control in multiple sclerosis (MS), where walking impairment is a leading source of disability, remain uncharacterized, and the supraspinal effects of AIH therapy are unknown. In a sham-controlled, double-blind crossover trial (NCT05164705), 23 adults with MS completed 5 sessions of AIH therapy and of sham therapy; magnetic resonance imaging (MRI) was performed before and after each t

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