The prevalence of type 2 diabetes mellitus among people with amyotrophic lateral sclerosis is increasing in the United States

Background: Type 2 diabetes mellitus (T2DM) has been associated with lower risk of ALS and prevalence of comorbid T2DM has been reported to be lower among people with ALS (PALS) compared to general population. We examined the trend of comorbid DM prevalence among PALS in comparison to overall population from 2011 to 2021 in the United States (US). Methods: We used multi-center electronic health records (EHRs) data within the GPC Reusable Observable Unified Study Environment (GROUSE) and validated algorithms to identify PALS with T2DM. Prevalence was defined by number of cases per population in

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