medRxiv PreprintsInternational5 November 2026
The Para-ISS Dural Space Enhancement Sign: A Novel MRI Finding Independently Associated With Intracranial Atherosclerotic Burden
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Background: No dural enhancement sign centered on the inferior sagittal sinus (ISS) has been characterized. We observed a frequent, previously undescribed finding - para-ISS dural space enhancement (PISE) - at the free inferior margin of the falx cerebri. Objective: To define PISE, determine its detection rate in a large cross-sectional cohort, and characterize its correlates, in particular whether the pattern of association is compatible with an atherosclerosis-related dural mechanism. Methods: Consecutive contrast-enhanced intracranial vessel-wall MRI (VWI) examinations (May 2015-December 20
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