The Efficacy of Cefazolin and Ertapenem combination treatment for Persistent MSSA Bacteraemia: A ten-year multicentre retrospective cohort study.

Objectives Persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia is associated with significant morbidity and mortality. Cefazolin-ertapenem combination therapy has demonstrated synergistic activity in preclinical models and small case series, but comparative clinical evidence is lacking. Methods We conducted a multicentre retrospective review of all patients aged >18 years with persistent MSSA bacteraemia at two Queensland tertiary hospitals between January 2014 and December 2024. The primary outcome was time to blood culture sterilisation, compared between patients who

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