Symptom variability and treatment response in pernicious anaemia: a longitudinal daily symptom tracking study

Pernicious Anaemia is an autoimmune-mediated disorder of vitamin B12 absorption, managed using fixed-interval vitamin B12 replacement regimens. Despite treatment, many patients report persistent or recurrent symptoms, suggesting substantial inter-individual variability in treatment response. More tailored approaches may therefore be needed to reduce symptom burden and improve quality of life. This prospective observational study used high-frequency longitudinal digital symptom monitoring to characterise symptom dynamics and heterogeneity in treatment response. UK adults with pernicious anaemia

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