State-independent functional connectomic architecture captures transdiagnostic network alterations and clinical variation

Background: Psychiatric disorders show substantial overlap across diagnostic categories while differing markedly in clinical expression. Whether these shared abnormalities and individual differences are embedded in stable functional brain architecture rather than in state-specific connectivity remains unclear. Methods: We integrated functional connectomes across one resting-state and six task-based fMRI conditions in 377 participants from the YaleNeuroConnect cohort, including 223 healthy controls and 154 individuals with psychiatric disorders. Principal component analysis was applied to each

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