Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Analysis Reveals Immune Cell-Specific Mechanisms in Alzheimer's Disease

Objective: To integrate single-cell expression quantitative trait locus (sc-eQTL), Alzheimer's disease (AD) genome-wide association study (GWAS), and Bayesian colocalization analyses, in order to systematically identify candidate causal genes and potential immune mechanisms that specifically regulate AD risk in peripheral immune cells. Methods: Using the cis-eQTLs of 14 peripheral blood immune cell types from the OneK1K single-cell eQTL dataset as exposure data and the AD GWAS (GCST90565439) as outcome data, a two-sample Mendelian randomization (MR) analysis was performed. Weak instrumental va

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