Serum Vitamin D Levels do not Affect Susceptibility to EBV Infection. A Mendelian Randomization Study.

Abstract Introduction: Epstein-Barr virus (EBV) infection and low serum 25-hydroxyvitamin D (25OHD) levels are strongly associated with multiple sclerosis (MS). We investigated whether genetically proxied serum vitamin D levels are causally linked to EBV infection, assessed by serology and detectable EBV DNA, using Mendelian randomisation (MR). Methods: We conducted two-sample cis-MR using genetic instruments associated with serum 25OHD concentrations, restricted to variants near genes implicated in vitamin D metabolism. Outcomes included EBV seropositivity, antibody responses to four EBV anti

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