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medRxiv PreprintsInternational5 November 2026

Scleral Allograft-Reinforced Cyclodialysis Combined with Phacoemulsification or Performed as a Standalone Procedure: 24-Month Outcomes from the Multicenter CREST Study

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Introduction: Acellular scleral allograft-reinforced cyclodialysis is a bio-interventional surgery (BIOS) to lower intraocular pressure (IOP). We report 2-year efficacy and safety outcomes when the procedure is performed in combination with phacoemulsification and as a standalone procedure in eyes with open-angle glaucoma. Methods: Analysis of the multicenter CREST real-world evidence study of eyes undergoing allograft-reinforced cyclodialysis with AlloFlo Uveo (Iantrek, Inc., White Plains, NY; NCT05506423). Eyes attending the Month-24 visit were analyzed: 176 eyes undergoing phaco-combined su
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