Residual Symptoms and Quality of Life in Female Patients with Hypothyroidism and Cardiovascular Disease

Background Current clinical management of patients with hypothyroidism emphasizes thyroid hormone replacement at doses that normalize serum thyroid-stimulating hormone (TSH) levels. However, biochemical correction does not always translate into symptom resolution or restored health-related quality of life (QoL). We evaluated whether higher TSH levels within the reference range would be associated with worse Thyroid-Related Patient-Reported Outcome (ThyPRO)-39 scores, reflecting greater symptom burden. Objective The objective of this study was to assess residual symptoms and health-related qual

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