medRxiv PreprintsInternational31 October 2026
Repetitive negative thinking is associated with amyloid accumulation over 3 years in cognitively healthy adults
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Importance: Identifying potentially modifiable risk factors for Alzheimer's disease (AD) is a priority. Repetitive negative thinking (RNT) is a modifiable cognitive-emotional process common to many psychological risk factors for AD, including anxiety and depression. The psychological debt hypothesis proposes that RNT may itself increase risk for AD. Objective: To determine whether RNT symptoms are associated with change in established neurobiological markers of AD risk over time. Design: Longitudinal neuroimaging study with the IMAP/IMAP+ cohort. Setting: Monocentric with community-dwelling pa
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