medRxiv PreprintsInternational28 October 2026
Remote Ischemic Conditioning Modulates Spinal Reflex Excitability in Healthy Young Adults: A Pilot Randomized Controlled Trial
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Background: Remote ischemic conditioning (RIC), involving transient and sublethal bouts of ischemia and reperfusion, promotes neuroplasticity and motor learning. Although early clinical studies suggest supraspinal and muscular mechanisms underlying RIC, its influence on spinal reflex excitability - a key substrate for motor learning - remains poorly understood. Balance training alone is known to modulate spinal excitability, but whether RIC can enhance this training-induced adaptation has not been tested. Objective: This prospective single-blind, pilot randomized controlled trial (RCT) explore
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