Remodeling of α1-Acid Glycoprotein Glycoforms During Long-Term Calorie Restriction

AGP1 (-1 acid glycoprotein) is an acute phase immune response protein recently shown to influence leptin receptor activity and body weight regulation. AGP is a highly glycosylated protein, with 45% of its molecular weight made up by glycans, yet little is known about how the latter responds to metabolic interventions or its role in AGPs immunometabolic function. In this pilot study (n = 26), we evaluated the effect of calorie restriction (CR - 2years, 25% CR in non-obese adults) on N-glycosylation of AGP1. AGP1 has 5 glycosylation sites, of which sites IV and V are dominated by highly branched

This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program: especially if you are pregnant, nursing, taking medication, or managing a health condition.