medRxiv PreprintsInternational8 October 2026
REM sleep infraslow rhythms correlate with neuropsychiatric symptom severity
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Study objectives: Rapid eye movement (REM) sleep is commonly divided into phasic and tonic substates based on higher and lower oculomotor activity, respectively. Our previous study described an alternative framework in which REM temporal structure forms a continuum of infraslow rhythms (~0.01 Hz) across brain and body physiology. We now ask whether these infraslow rhythms vary with neuropsychiatric symptoms, given the long-standing but still inconsistent links between REM and mood- or trauma-related disorders. Methods: Using a cross-sectional polysomnographic dataset from male veterans, we exa
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