Biological network identifies pathways linking mental health drugs to adverse weight-related side effects

The majority of antidepressant and antipsychotic medications are underscored by their common weight-related adverse drug events; medication-induced weight gain is a central hindrance to psychiatric treatments because it impacts patient compliance and results in a cascade of secondary comorbidities with negative health outcomes. Here, we use network pharmacology approaches to characterize the multiple effects of drugs and explore the mechanisms by which drug-molecule interactions lead to adverse drug events. We first construct a robust interactome containing 17,293 proteins (network vertices) a

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