Menopause timing, epigenetic aging and blood-cell traits

Menopause timing links reproductive lifespan with later life health, motivating investigation of its molecular and hematological correlates. We combined Generation Scotland analyses of women sampled at or after reported menopause (n = 1,444) and initially menstruating women followed for GP ascertained menopause onset (n = 1,725; 251 events) with bidirectional and multivariable Mendelian randomization. Higher age adjusted GrimAge V1, GrimAge V2 and DunedinPACE corresponded to 0.34 to 0.40 years earlier menopause per SD in the retrospective cohort at nominal P < 0.05. Prospective associations we

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