medRxiv PreprintsInternational30 October 2026
Relative Importance of Positive and Potentially Traumatic Childhood Experiences in Explaining Multiple Sclerosis Symptoms
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The original adverse childhood experiences study linked childhood experiences to health in adulthood. Since then, other traumatic and adverse childhood experiences (TRACEs) and positive childhood experiences (PCEs) have also been linked to physical and mental health. However, little research has examined these experiences among people with Multiple Sclerosis (MS). This study examined whether cumulative and individual childhood experiences explained variability in symptom burden in adults with MS. Participants were 467 adults with MS (Mage = 41.5, 45% female) who completed measures of pain, sub
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