Pupil size-resting state network coupling in major depressive disorder: a longitudinal iTBS study

Altered central-peripheral autonomic nervous system communication plays a key role in major depressive disorder (MDD). In this context, pupillary dynamics may be considered a non-invasive peripheral proxy of treatment-related changes during intermittent theta-burst stimulation (iTBS) in MDD. However, the relationship between spontaneous pupillary fluctuations and the resting-state functional networks (RSNs) involved in MDD is still underexplored. Here, we investigated longitudinal changes in pupil-RSN coupling in patients with MDD undergoing an iTBS intervention. Resting-state functional magne

This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program: especially if you are pregnant, nursing, taking medication, or managing a health condition.