Prebiotic Inulin for Late-Reproductive Individuals (P.I.L.I. study): A Protocol for a Placebo-Blind, Cross-Over Randomized Controlled Trial

Background: Perimenopause is a transitional stage preceding menopause, characterized by hormonal fluctuations and physiological changes that may increase cardiometabolic risk. Emerging evidence suggests that the gut microbiome may influence these changes through estrogen metabolism and microbial metabolite production. Inulin, a prebiotic fiber that modulates the gut microbiome, may offer a targeted nutritional strategy; however, its effects during perimenopause remain largely unexplored. Objective: This proof-of-concept study evaluates the effects of short-term inulin supplementation on gut mi

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