Postnatal CMV acquisition risk is not increased among children who are HIV-exposed, uninfected versus HIV-unexposed in the setting of optimized maternal ART

Historically, children who are HIV-exposed, uninfected (CHEU) had higher incidence and earlier postnatal acquisition of cytomegalovirus (CMV) than children who are HIV-unexposed. We assessed whether this difference persists in the current era of universal antiretroviral therapy (ART). Women without HIV and women living with HIV (WLHIV) on ART for [≥]6 months were recruited in pregnancy in Nairobi, Kenya and followed weekly with their infant for 12 months postpartum; 89% of WLHIV initiated ART pre-conception. Log10-CMV DNA levels were measured in infant urine, oral swabs, and plasma, and in

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