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medRxiv PreprintsInternational2 November 2026

Placental Klotho responses to supervised prenatal exercise: findings from the PLACENTRAINING study

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Background: Regular exercise during pregnancy improves maternal and neonatal outcomes; however, the molecular pathways underlying placental adaptations to prenatal exercise remain poorly understood. Klotho is a cytoprotective protein involved in the regulation of oxidative stress, metabolic homeostasis, and cellular resilience, yet whether placental Klotho concentrations are associated with prenatal exercise has not been previously investigated. Aims: The primary aim of this study was to examine whether participation in a supervised concurrent exercise program during pregnancy is associated wi
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