Physician Decision-Making in Acute Ischemic Stroke with and without a Guideline-Encoded Clinical Decision Support System

Background: Applying extensive, frequently revised guidelines at the point of care is difficult. We evaluated whether acute ischemic stroke decisions made with LUCID, a clinical decision support system encoding the 2026 American Heart Association/American Stroke Association guideline, were more often guideline-concordant than decisions made without it. Methods: In this pilot vignette study, clinicians completed 8 stroke vignettes (24 questions) alone (Arm A) or with access to LUCID (Arm B). Questions bundling recommendations of different classes were split into nodes (29 decision points). The

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