medRxiv PreprintsInternational6 November 2026
Path to Prevention Platform Trial in Early-Stage Neuronal Alpha-Synuclein Disease: Study Design
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The development of biologically targeted therapeutics (BTTs) that slow Parkinson's disease progression has been hampered by a reliance on testing interventions in clinically defined populations with already advanced pathobiology. Publications on the biological definition and classification of neuronal a-synuclein disease (NSD), and the development of the NSD integrated staging system (NSD-ISS), have generated a framework for identifying individuals with NSD prior to the emergence of a clinically defined syndrome. Path to Prevention (P2P) is a phase 2A, randomized, double-blind, placebo-control
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