Parent-of-Origin-Aware Genomic Analysis to Enhance Cascade Testing in Pancreatic Cancer: A Population-Based Study

Identifying germline pathogenic variants has therapeutic value for pancreatic ductal adenocarcinoma (PDAC) patients and critical implications for cascade genetic testing in families, the latter being an increasing focus for public health genomic initiatives. We measured cascade testing rates for one hundred consecutive hereditary PDAC probands (March 2014-December 2023) and assessed the potential impact of using a novel technology, Parent-of-Origin-Aware genomic analysis (POAga) to enhance cascade testing. POAga requires a new blood sample and enables variant segregation to the maternal or pat

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