medRxiv PreprintsInternational4 November 2026
Olfactory Function in Preclinical Alzheimer's Disease: A Multi-Cohort Study
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Introduction: Olfactory impairment is an early feature of Alzheimer's disease (AD). However, it is unclear if olfactory performance reflects early pathological changes during preclinical AD and/or predicts subsequent clinical progression among characterized cognitively normal (CN) individuals. We aimed to determine whether odor identification differs by amyloid status, relates to medial temporal lobe (MTL) tau burden and morphometry, and predicts longitudinal conversion to mild cognitive impairment (MCI). Methods: We analyzed data from 257 cognitively normal (CN) older adults enrolled in PREVE
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