Non-contact fingertip video to differentiate dengue haemorrhagic fever in plasma leakage from dengue fever: A prospective proof-of-concept cohort study

Most patients with dengue recover without intervention, but a minority develop plasma leakage that threatens the circulation, and differentiating them is the central problem in dengue care. Platelet count is the marker in routine serial use and is itself one of the four defining criteria of dengue haemorrhagic fever (DHF), so thrombocytopenia in dengue fever (DF) can overlap with DHF on the very marker used to distinguish them. We asked whether a non-contact optical signal carries discriminative information beyond platelet count. We conducted a prospective observational cohort study at a natio

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