Music-Synchronized Gamma Light Stimulation Strengthens Theta-Gamma Coupling in Older Adults with Cognitive Impairment: Results from a Randomized Feasibility Trial

Noninvasive clinical innovations for restoring gamma activity via sound and light stimulation have the potential to improve memory and cognitive abilities in Alzheimer's disease. We assessed whether pairing music with theta- and gamma-band light changes memory-supporting neural dynamics, and whether those changes track cognition. In an ongoing randomized feasibility trial, 38 older adults with cognitive impairment completed eight weeks of an audiovisual intervention. The treatment group (n = 19) listened to self-selected music while viewing light stimulation that consisted of a 39-Hz gamma-ban

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