Multimodal Analysis of Transcriptional Regulation in the Dorsolateral Prefrontal Cortex Enhances Alzheimer's Disease Risk Gene Discovery

Recent transcriptome-wide association studies (TWASs) of Alzheimer's disease (AD) dementia have identified risk genes whose effects are potentially mediated through gene expression, but most do not consider other transcriptomic regulatory modalities that may contribute to AD genetic risk. To address this gap, we profiled transcriptomic quantitative traits across six modalities--gene expression, RNA stability, isoform ratios, splice junction usage, alternative TSS and polyA usage--from dorsolateral prefrontal cortex RNA-seq data tissue (n=1,035). We profiled 396,344 transcriptomic traits, which

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