Modulating Amygdala Responses in Major Depressive Disorder using Naturalistic Neurofeedback with Emotional Faces

Emotion regulation is critical to mental health, and its disruption can lead to psychiatric conditions such as major depressive disorder (MDD). MDD encompasses diverse symptoms, including anhedonia and anxiety, which may be associated with distinct patterns of altered neural activity. Interventions that address the neural mechanisms underlying these symptom dimensions may improve treatment efficacy. We investigated an adaptive, naturalistic real-time functional magnetic resonance imaging neurofeedback paradigm designed to differentially target anhedonia and anxiety through bidirectional amygda

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