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medRxiv PreprintsInternational1 November 2026

Metabolomic Signatures of Habitual Physical Activity in Childhood

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Physical activity (PA) supports health across the life course, yet the biological pathways linking habitual PA to long-term health remain incompletely understood. Metabolomics provides a powerful tool to study PA-related metabolic adaptations, but how habitual PA shapes the metabolome in childhood remains poorly characterized. Addressing this gap, we examined cross-sectional associations between accelerometer-measured habitual PA and the plasma metabolome in 515 children aged 5.5 to 11 years from the European Childhood Obesity Project (CHOP) and additionally determined whether associations dif
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