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medRxiv PreprintsInternational5 November 2026

LOW-FREQUENCY DEEP BRAIN STIMULATION PROMOTES LONG-TERM OROFACIAL MOTOR RECOVERY AFTER TRAUMATIC BRAIN INJURY: A CASE STUDY

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Diffuse axonal injury (DAI), a subtype of traumatic brain injury (TBI), can disrupt corticobulbar pathways, leading to chronic deficits in speech and swallowing. We present a first-in-human case study demonstrating the long-term therapeutic potential of low-frequency continuous deep brain stimulation (DBS) of the motor thalamus to restore corticobulbar function in a patient with severe DAI and persistent dysarthria and dysphagia. The patient underwent bilateral motor thalamus DBS implantation one-year post-injury for treatment of post-traumatic action tremor, and stimulation was delivered chro
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