medRxiv PreprintsInternational6 November 2026
Longitudinal Participation and Cognitive Score Interpretation in the J-TRC Webstudy
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INTRODUCTION: Web-based registries support remote cognitive assessment for Alzheimer's disease research, but participant-driven reassessment raises questions about long-term data yield and interpretation of repeated scores. We evaluated data contribution, selective observation, and retest-dependent estimates of cognitive change in the Japanese Trial-Ready Cohort (J-TRC) Webstudy. METHODS: We analyzed over six years of J-TRC Webstudy data (launched October 2019; registrations through March 31, 2025; assessments through May 31, 2026). We examined data contribution, inactivity, reactivation, scor
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