Interferon-activated neutrophils characterize coronary microvascular dysfunction in women with ANOCA

Background | Coronary microvascular dysfunction (CMD) is a common cause of ischemic symptoms in patients with angina and non-obstructive coronary arteries (ANOCA), predominantly women. Neutrophils may contribute to CMD via vascular inflammation and endothelial injury. We therefore investigated neutrophils and coronary endothelial cells in women with ANOCA. Methods | In this cross-sectional study, we collected blood samples from ANOCA patients (n=123, 84% women) undergoing coronary function testing. Complete blood counts (CELL-DYN, n=123) and neutrophil activation (AQUIOS, n=76) were assessed.

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